Cognitive and neuropsychological trajectories in patients with mixed neurodegenerative pathologies.

ABSTRACT:

Introduction

The presence and interaction of multiple comorbid neuropathologies are a major contributor to the worldwide dementia burden.

Methods

We analyzed 1183 subjects from the National Alzheimer's Coordinating Center dataset with various combinations of isolated and mixed neurodegenerative pathologies and conducted mixed-effects multiple linear regression modeling to comprehensively compare the neurocognitive and neuropsychological trajectories between groups over time.

Results

In combination with Alzheimer's disease neuropathologic change, various combinations of limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy, Lewy body dementia, and cerebrovascular disease further impair global cognition and specific neurocognitive dom

SUBMITTER: Almeida FC 

PROVIDER: S-EPMC12322323 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature