Integrative transcriptomic analysis reveals oligodendrocyte lineage switching in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a chronic disease of the central nervous system. The occurrence of MS is a phased process while its cause is still unclear. Here, by combining white matter single-nucleus transcriptomic datasets from MS and control samples, we found molecular crosstalk between oligodendrocytes (OLs) and immune cells involved in MS pathology. Using a machine learning approach, we identified oligodendrocyte precursor cells (OPCs) and OL subtypes at various developmental stages. We highlighted their unique molecular characteristics and analyzed their distribution throughout development, adulthood, and in different regions impacted by MS. We also found an increased number of Pre-OPCs and newly formed oligodendrocytes (NFOLs) in normal appearing white matter (NAWM), which were scarcel

SUBMITTER: Yan ZZ 

PROVIDER: S-EPMC12322325 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature