Electroencephalogram features support the retrogenesis hypothesis of Alzheimer's disease: Exploratory comparison of brain changes in aging and childhood.

ABSTRACT: BackgroundThe retrogenesis hypothesis (RH) suggests that the functional and cognitive decline observed in Alzheimer's disease dementia mirrors in reverse order the brain development during childhood and adolescence.ObjectiveEquivalent electroencephalogram (EEG) patterns between older adults across different cognitive decline stages and children across different brain maturation stages were directly compared.MethodsTo capture the complex patterns that allow for such a comparison, a regression model was trained on EEG data from N = 510 older adults, at different stages of cognitive reserve, to identify EEG markers predictive of global cognitive status. The model was then applied on the same EEG markers of N = 696 children across different ages.ResultsThe model predicted MMSE scores with an a

SUBMITTER: Saraiva JA 

PROVIDER: S-EPMC12322342 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature