Changes in the prognosis of CADASIL over time: a 23-year study in 555 individuals.

ABSTRACT:

Background

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of stroke and is associated with early-onset stroke and dementia. Whether its clinical phenotype is becoming milder with better risk factor treatments and other care improvements is unknown. In a large longitudinal CADASIL cohort, we determined whether the prognosis has changed over 23 years.

Methods

Patients were identified from the Cambridge CADASIL register and the UK Familial stroke study. Change in age at stroke over the time of recruitment was determined using linear mixed-effects model, and the impact of genetic and vascular risk factors on stroke and dementia risk was further evaluated using Cox proportional hazard regressi

SUBMITTER: Sukhonpanich N 

PROVIDER: S-EPMC12322386 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature