Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage.

ABSTRACT: Hyaline cartilage is a dense avascular tissue with low regenerative potential, present at the ends of the diarthrodial joints and in the cartilage growth plate. Skeletal diseases often result from extracellular changes in this tissue; however, studies of these are hindered by the tissue complexity, the difficulty in obtaining human material, and the cost of generating animal models. Recent developments in tissue engineering are opening possibilities to develop mechanoresponsive zonally stratified models of cartilage in vitro. In this study, we optimized a 3D model of cartilage using chondroprogenitor cells cultured for 21 days in 2% agarose hydrogel constructs with daily dynamic compression. Our hydrogel constructs developed pericellular matrices with nanostiffness comparable with native m

SUBMITTER: Farcasanu MV 

PROVIDER: S-EPMC12322637 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature