Harnessing Bifunctional N-Benzoyloxyamides for Photoredox Amidative Dual Functionalizations of Alkenes.

ABSTRACT: Here, we present a photocatalytic strategy for the intermolecular dual functionalizations of alkenes using N─O bifunctional reagents in an atom-economical fashion. By leveraging N-benzoyloxyamides as bifunctional precursors for generating both amidyl radical and internal O-nucleophiles, this approach achieves chemoselective olefin amidation with simultaneous incorporation of additional functional groups. The current method readily accesses a range of doubly functionalized amino products through 1,2-amidooxygenation, amidoazidation, and formal anti-Markovnikov hydroamidation. Mechanistic studies revealed that the selective interplay of radical and ionic pathways is operative to enable a unified platform for this olefin dual functionalization.

SUBMITTER: Ryoo H 

PROVIDER: S-EPMC12322644 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature