A Platform for the Development of Highly Red-Shifted Azobenzene-Based Optical Tools.

ABSTRACT: Azobenzenes are versatile photoswitches that can be used to generate elaborate optical tools, including photopharmaceuticals. However, the targeted application-guided design of new photoswitches with specific properties remains challenging. We have developed synthetic protocols for derivatives of the dfdc (di-ortho-fluoro-di-ortho-chloro) azobenzene scaffold with chemical alterations in the para-/ortho-positions and performed an in-depth study into the effects of their structures on their photophysical properties with an emphasis on the n → π* absorption band using NMR, UV-vis, and X-ray analysis. The data was used to establish and validate a computational approach that allows to compute realistic UV-vis spectra by combining TD-DFT excited-state calculations from 6000 thermally accessible

SUBMITTER: Lutzel K 

PROVIDER: S-EPMC12322654 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature