Performance of computed tomography and magnetic resonance morphometry in evaluating brain atrophy in Down syndrome.

ABSTRACT:

Background

To compare the performance of computed tomography (CT) with that of magnetic resonance imaging (MRI) in assessing brain atrophy in Down syndrome (DS).

Methods

Retrospective comparison of CT-derived gray and white matter measurements with those obtained by MRI using voxel-based morphometry (VBM) in adults with DS who underwent both scanning modalities with a maximum interval of 1 year. The concordance of both tests was compared across sample quartiles.

Results

Eleven of 23 participants had some degree of cognitive decline. When comparing VBM outputs of both imaging techniques, an overlap of voxels negatively correlated with dementia severity was observed in the right temporal lobe. Observed agreement was 92.3% (quadratic-weighted kappa index 0.71) for both g

SUBMITTER: Sanchez-Moreno B 

PROVIDER: S-EPMC12322686 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature