The infection of mycovirus down regulates <i>Aa-milR13</i> to weaken the pathogenicity of the <i>Alternaria alternata</i> f. sp. <i>mali</i>.

ABSTRACT: This study explored the association between differentially expressed miRNA Aa-milR13 in Alternaria alternata f. sp. mali strains with and without virus infection, and the regulation of fungal host pathogenicity by viruses. MiRNA sequencing was conducted on a hypovirulent strain (QY21) with compound infection of Alternaria alternata chrysovirus 1 (AaCV1) and Alternaria alternata magoulivirus 1 (AaMV1), a hypovirulent strain (QY21-C1) with single AaMV1 infection, and a virus-free strain (QY21-C2). Fourteen miRNAs with significant differential expression were identified. Aa-milR13 was significantly downregulated in virus-infected strains and validated by RT-qPCR. Structural analysis of the Aa-milR13 sequence identified that the mature Aa-milR13 is located at the 5' end of its pr

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12322705 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature