The J-shaped association between the ratio of neutrophil counts to prognostic nutritional index and mortality in ICU patients with sepsis: a retrospective study based on the MIMIC database.

ABSTRACT:

Background

The ICU faces persistent challenges with sepsis, marked by systemic inflammation and metabolic disruptions, often leading to poor outcomes. Despite advances, reliable biomarkers for predicting sepsis outcomes are needed. This study introduces a novel indicator combining neutrophil count and prognostic nutritional index (PNI) to improve predictive accuracy by addressing both inflammatory and nutritional-immune aspects.

Methods

We conducted a retrospective cohort study analyzing data from the MIMIC-IV database, focusing on adults diagnosed with sepsis per Sepsis 3.0 criteria. We excluded those younger than 18, with ICU stays under 48 hours, multiple ICU admissions, or incomplete data. Participants' neutrophil counts/PNI ratios were calculated and correlated with 30,

SUBMITTER: Lou J 

PROVIDER: S-EPMC12322749 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature