Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression.

ABSTRACT:

Importance

The limited success of major depressive disorder (MDD) treatments is largely due to the disorder's etiological and pathophysiological heterogeneity. Addressing this heterogeneity is essential for developing accurate prognostic models and personalized treatment strategies.

Objective

To characterize MDD heterogeneity using a mechanism-first latent profile analysis based on environmental, neurostructural, and neurofunctional indicators, and to validate profiles via associations with MDD course, severity, and antidepressant treatment remission.

Design, setting, and participants

This cross-sectional study used data from 2 Canadian Biomarker Integration Network in Depression (CAN-BIND) studies: CAN-BIND-1 (2014-2017), a multicenter outpatient antidepressant trial

SUBMITTER: Rowe J 

PROVIDER: S-EPMC12322798 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature