Genetic correlations of alcohol consumption and alcohol use disorder with sex hormone levels in females and males.

ABSTRACT:

Background

Alcohol consumption behaviors and alcohol use disorder risk and presentation differ by sex, and are associated with blood concentrations of the steroid sex hormones, testosterone and estradiol, and their regulatory binding proteins, sex hormone binding globulin (SHBG) and albumin. Genetic variation is also associated with alcohol consumption, alcohol use disorder, and levels of these hormones and binding proteins.

Methods

To assess the contribution of genetic factors to previously described phenotypic associations between alcohol-use traits and sex-hormone levels, we estimated genetic correlations (r_g) using summary statistics from prior published, large sample size genome-wide association studies (GWAS) of alcohol consumption, alcohol dependence, testo

SUBMITTER: Waller TC 

PROVIDER: S-EPMC12322815 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature