Dose-dependent effects of testosterone on proteins related to nitric oxide signaling pathway and trophic factors in the spinal cord of adolescent trained rats.

ABSTRACT:

Introduction

Endurance training plays an important role in, for example, triathlon, marathon, or road cycling and in combination with strength training. Adolescence has been associated with increased interest among of young people, especially boys, in strength-related and endurance sports or body-building. Anabolic androgen steroid use is a public health threat. The present study aimed to estimate the effect of endurance training, two doses of testosterone, and the combination of these stimuli on the level and activity of proteins related to the nitric oxide (NO) signaling pathways in the spinal cord in adolescent male rats.

Methods

Adult male Wistar rats were trained using a motor-driven treadmill for 6 weeks (40-60 min, 5 times per week) and/or were treated for 6 weeks wit

SUBMITTER: Nierwinska K 

PROVIDER: S-EPMC12322838 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature