A stable systemic infection of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) in cynomolgus macaques produces extended window for therapeutic intervention.

ABSTRACT:

Introduction

Staphylococcus aureus is a common gram-positive commensal that, upon entering the bloodstream, can cause devastating illness and death within hours or days. Methicillin-resistant S. aureus (MRSA) infections, now a leading cause of bloodstream infections worldwide, pose significant challenges due to their rapid progression, high mortality rates, and limited therapeutic options. While there are prevalent small animal models of experimental MRSA infection, there has been minimal development of larger mammalian models capable of recapitulating clinical aspects of human systemic MRSA infection.

Methods

Following a pilot study to determine the optimal dose and route to establish systemic MRSA infection, we challenged six cynomolgus macaques with 10⁹

SUBMITTER: Gamblin AJ 

PROVIDER: S-EPMC12322839 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature