Mannose-binding lectin insufficiency is associated with airway Haemophilus colonization and a higher risk of post-RSV bronchiolitis recurrent wheezing.

ABSTRACT:

Objective

To investigate whether mannose-binding lectin (MBL) insufficiency influences the airway microbiota composition and development of subsequent recurrent wheezing in infants with severe respiratory syncytial virus (RSV) bronchiolitis.

Methods

Sixty-seven infants who were hospitalized during an initial episode of severe RSV bronchiolitis at 6 months of age or less were included in the study and followed up until the age of 3 years. Serum and sputum samples were collected. The serum MBL concentrations were determined by ELISA; the sputum microbiota and cytokines were analyzed by 16S rRNA-based sequencing and multiplex immunoassay, respectively.

Results

Twenty-six infants developed recurrent wheezing by the age of 3 years, and 41 did not. The rate of MBL insuffici

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12322870 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature