Visible-Light-Triggered and Rhodamine B-Catalyzed Thiolation of Bromoalkynes: Accessing Alkynyl Thioethers.

ABSTRACT: A visible-light-mediated C(sp)-S^II cross-coupling of 1-haloalkynes with aryl/alkyl thiols is reported. The reaction was catalyzed by Rhodamine B under purple LED irradiation in an open-air atmosphere. Rhodamine B is a basic xanthene dye that is easily degradable and highly soluble in water. A wide range of 1-haloalkynes efficiently coupled with aryl and alkyl thiols, obtained corresponding alkynyl thioethers in moderate to excellent yields. Metal-free, room temperature, easy operation, and broad substrate scope are the salient features of the established protocol.

SUBMITTER: Bai R 

PROVIDER: S-EPMC12322964 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature