Toxoplasma gondii-induced host's high secretion of 25-hydroxycholesterol for immunoprotection.

ABSTRACT:

Background

Toxoplasma gondii, a parasitic protozoan affecting approximately one-third of global population, causes opportunistic toxoplasmosis. It penetrates barriers to immune-privileged sites, causing encephalitis, retinochoroiditis, and fetal damage. The infection may be linked to neurodegenerative and psychiatric disorders. The T. gondii-host interaction mechanism remains central to understanding its pathogenesis. The changes in small molecule metabolites after infection, which affects the central nervous system (CNS) normal function, have been poorly characterized.

Methods

The metabolic alterations in brain tissues of sv129 mice infected by T. gondii at 9 days post-infection (DPI) were analyzed through untargeted metabolomic detection. Cholesterol metabolic reprogrammin

SUBMITTER: Yang ZH 

PROVIDER: S-EPMC12323074 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature