Exploring the relationships between CT and pathological characteristics and gene mutations in neoplastic ground glass nodules.

ABSTRACT:

Background

Neoplastic ground glass nodules (GGNs) are relatively indolent tumors, with slow progression in invasiveness and computed tomography (CT) features. This study aimed to explore the correlation between pathological and CT characteristics and gene mutations in neoplastic GGNs.

Methods

We retrospectively analyzed 1,348 neoplastic GGNs from January 2019 to November 2022, including 290 adenocarcinomas in situ (AIS), 448 microinvasive adenocarcinomas (MIA), and 610 invasive adenocarcinomas (IAC). The correlations between patients' characteristics, pathological subtypes and grades, CT features, changes in follow-up, and gene mutations were analyzed.

Results

Solid component (odds ratio [OR] = 1.493; P = 0.014), larger size (OR = 1.049; P = 0.006), ill-defined bounda

SUBMITTER: Zhao ZY 

PROVIDER: S-EPMC12323122 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature