Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers.

ABSTRACT:

Background

Previous study has overlooked the heterogeneity between hemispheres and the knowledge of brain temporal dynamics in tobacco use disorder (TUD) individuals was limited. Traditional whole-brain based approaches hampered the exploration of dynamic functional connectivity at the hemisphere level.

Methods

We recruited 110 male subjects, including 70 smokers (32 high dependence smokers, 38 low dependence smokers) and 40 non-smokers, then obtained their rs-fMRI data and smoking clinical scales. The functional connections of whole-brain were decomposed into inter-hemispheric and intra-hemispheric connections. Meanwhile, sliding window method was used to evaluate inter- and intra-hemispheric dynamic functional connectivity density (dFCD) variability. Finally, correlation a

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12323142 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature