Integrated multiple machine learning and Mendelian randomization reveal LTF gene as a prognostic biomarker for nonspecific orbital inflammation.

ABSTRACT:

Background

Nonspecific orbital inflammation (NSOI), also known as idiopathic orbital inflammation, comprises a heterogeneous group of immune-mediated disorders affecting orbital tissues, unified by the absence of a defined etiology. Lactotransferrin (LTF), an iron-binding glycoprotein, exerts potent antimicrobial activity by sequestering iron essential for microbial growth, and demonstrates broad-spectrum antibacterial, antiviral, and antifungal properties.

Methods

LTF was identified through the intersection analysis of common DEGs from datasets GSE58331 and GSE105149 from the GEO database, alongside immune-related gene lists from the ImmPort database, using Multiple Machine learning and WGCNA analysis. GSEA and GSVA were conducted with gene sets co-expressed with LTF. To fu

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12323148 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature