Visualizations of autoregulatory insults in moderate-to-severe paediatric traumatic brain injury: a secondary analysis from the multicentre STARSHIP trial.

ABSTRACT:

Background

Paediatric traumatic brain injury (TBI) is a heterogeneous condition with age-dependent differences in systemic and cerebral physiology, making cerebral perfusion pressure (CPP) challenging to target. Monitoring cerebral autoregulation using the pressure reactivity index (PRx) and deriving an autoregulatory optimal CPP (CPPopt) may personalize treatment, but evidence in children remains limited. In this multicentre paediatric TBI study, we aimed to explore and visualize PRx and CPPopt in relation to outcome.

Methods

In this secondary analysis of the prospective, multicentre study (STARSHIP), 98 paediatric TBI patients (1-16 years) from 10 paediatric intensive care units, in the UK, between 2018 and 2023, with high-frequency physiological data and 12-month GOS-E Pe

SUBMITTER: Svedung Wettervik T 

PROVIDER: S-EPMC12323160 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature