Association between dietary theobromine and age-related macular degeneration: results from NHANES 2005-2008 and in vitro experiments.

ABSTRACT:

Objective

To investigate the relationship between theobromine and age-related macular degeneration (AMD) using a nationwide representative sample of adults and in vitro experiments.

Methods

We analyzed data from the 2005-2008 years of the National Health and Nutrition Examination Survey (NHANES), which included 5485 participants with available data on dietary theobromine intake and AMD. Multivariable logistic regression and smoothing curve fitting were used to examine the potential correlations. The inflection point was determined using a two-piecewise linear regression. Interaction tests and subgroup analyses were also conducted. In vitro experiments were conducted to investigate the effects of theobromine on cell proliferation, intracellular reactive oxygen species (ROS) l

SUBMITTER: An N 

PROVIDER: S-EPMC12323205 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature