Beyond blood-brain barrier disruption and molecular weight: compartmental kinetics of S100B and NSE for neurological prognostication after cardiac arrest.

ABSTRACT:

Background

The prognostic value of serum biomarkers after out-of-hospital cardiac arrest (OHCA) depends on timing, but the physiological basis remains unclear. We investigated whether blood-brain barrier (BBB) integrity and biomarker-specific properties explain the time-dependent differences in prognostic performance.

Methods

This retrospective study included comatose adult OHCA survivors who underwent paired serum and cerebrospinal fluid (CSF) measurements of neuron-specific enolase (NSE; 47 kDa) and S100 calcium-binding protein B (S100B; 21 kDa) at 0 (H0), 24 (H24), 48 (H48), and 72 (H72) h after return of spontaneous circulation. BBB disruption was assessed using the CSF/serum albumin quotient (Q_A). Prognostic performance was assessed using AUC analysis for 6-m

SUBMITTER: Jeon SY 

PROVIDER: S-EPMC12323214 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature