What is the best cutoff point of leukocyte esterase for diagnosis of periprosthetic joint infections? a systematic review and meta-analysis.

ABSTRACT:

Background

Periprosthetic joint infection (PJI) is a significant complication following total joint arthroplasty that demands rapid, accurate diagnosis. The leukocyte esterase (LE) test shows promise, but studies vary in cut-off values and omit the centrifugation's effect. In this study, we assessed the sensitivity and specificity of the LE test across different cut-off values, both with and without centrifugation. We aimed to identify the optimal threshold for diagnosing PJI and to compare its diagnostic odds ratio (DOR) to those of biomarkers recommended by the International Consensus Meeting (ICM).

Methods

A comprehensive literature search was performed in PubMed, Scopus, Web of Science, and Embase up to May 2024. Studies were included if they evaluated the diagnostic acc

SUBMITTER: Poursalehian M 

PROVIDER: S-EPMC12323279 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature