Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast.

ABSTRACT:

Background

Genetic information is stored on multiple chromosomes in eukaryotic organisms and is passed on to offspring through cell division. How chromosome number influences cell division and chromosome segregation is not yet understood.

Results

In this study, we use artificial chromosome-fusion fission yeast cells, which contain one or two chromosomes, as models to investigate the effects of a reduced chromosome number on mitosis and meiosis. In mitosis, chromosome number reduction, particularly full fusion into one chromosome, prolongs mitotic duration in a manner dependent on the spindle assembly checkpoint and improves chromosome segregation accuracy in spindle assembly checkpoint-deficient cells. By contrast, in meiosis, chromosome number reduction impairs prophase osc

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12323286 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature