Reliability of CMV-IgG kinetics in the diagnosis of CMV primary infection: sensitivity, specificity, and clinical implications.

ABSTRACT: Diagnosis of cytomegalovirus (CMV) primary infection (PI) during pregnancy relies on serology (CMV-IgG, IgM, and IgG avidity). However, as for toxoplasmosis, subsequent serology testing 3-5 weeks later is often performed to confirm the diagnosis. In this study, we aimed to show that testing CMV-IgG with different assays may lead to misinterpretation of CMV-IgG kinetics and to determine the sensitivity and specificity of CMV-IgG stability and significant increase to exclude or confirm recent CMV PI. We conducted a retrospective study on (i) a CMV-IgG external quality control program (2015-2022) and (ii) on CMV serology results obtained in our virology laboratory (2013-2023) in pregnant women with positive CMV-IgM and a subsequent serum sample collected 3-5 weeks later. Analysis of 21 CMV-Ig

SUBMITTER: Portet Sulla V 

PROVIDER: S-EPMC12323311 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature