Collateral sensitivity and cross-resistance in six species of bacteria exposed to six classes of antibiotics.

ABSTRACT: De novo resistance can develop in bacteria as a result of exposure to sublethal concentrations of antibiotics. Once the strain has become resistant to an initial antibiotic, this can cause cross-resistance or collateral sensitivity to a second antimicrobial. Specific collateral sensitivity is rarely conserved across species because the mechanisms triggered in different microorganisms to resist antibiotics are often different. In this study, we explored which collateral sensitivity or cross-resistance networks are present in six species of bacteria with induced de novo resistance. These six species were induced to become resistant to amoxicillin/cefepime, enrofloxacin, kanamycin, tetracycline, erythromycin, and chloramphenicol (T. Pulingam, T. Parumasivam, A. M. Gazzali, A. M.

SUBMITTER: Wang X 

PROVIDER: S-EPMC12323328 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature