Population-based microbiological characterization of <i>Nocardia</i> strains causing invasive infections during a multiyear period in a large Canadian healthcare region.

ABSTRACT: The role of specific Nocardia species in human infections continues to expand as advanced methods enable species/species complex identification. We conducted a multiyear population-based (2010-2022) characterization of invasive Nocardia spp. Isolates were analyzed using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and 16S rRNA gene sequencing. A total of 94 cases and 117 unique 16S rRNA gene sequences were evaluated from pulmonary (53%), skin and soft tissues (SSTIs) (29%), central nervous system (CNS) (7%), bloodstream (6%), and other sites of infection. Infections were mainly caused by three species complexes: N. farcinica (n = 20, 21.3%), N. cyriacigeorgica (n = 16, 17%), and N. nova (n

SUBMITTER: Church D 

PROVIDER: S-EPMC12323336 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature