High proportion of tuberculosis recent transmission in rural areas of Northeastern China: a 3-year prospective population-based genotypic and spatial analysis in Hinggan League, China.

ABSTRACT: Tuberculosis (TB) remains a significant public health challenge in China, particularly in rural areas like Hinggan League (HL), Inner Mongolia. Understanding the genetic diversity and transmission dynamics of Mycobacterium tuberculosis (MTB) strains is crucial for effective TB control. We conducted a prospective study from 2021 to 2023, sequencing 221 MTB isolates from HL. After quality control, 210 cases were analyzed. The genomic clustering rate was calculated to evaluate the level of recent transmission. Risk factors were identified by logistic regression analysis. Geospatial analysis was conducted with kernel density estimation. The majority of strains belonged to sub-lineage 2.2.1 in lineage 2 (L2), also known as the Beijing family (89.0%, 187/210), while the remainder belonged

SUBMITTER: Ou X 

PROVIDER: S-EPMC12323342 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature