Molecular epidemiology and clinical characteristics of carbapenem-resistant <i>Klebsiella pneumoniae</i> bloodstream and pneumonia isolates.

ABSTRACT: Appropriate antibiotic therapy in patients with carbapenem-resistant Klebsiella pneumoniae (CRKp) infections often requires knowledge of resistance mechanisms. Therefore, we aimed to define the clonal diversity, mechanisms of carbapenem resistance, potential for carbapenem resistance transmissibility, virulence gene repertoire, and potential clinical impact of these genetic elements in patients with CRKp bloodstream infection and/or pneumonia, which are associated with high mortality. Clinical data and CRKp isolates at a site in Singapore and in the United States were examined. Whole-genome sequencing and bioinformatic analysis of CRKp isolates were performed. In total, 125 patients (n = 118 from Singapore; n = 7 from the United States) were included. Clonal diversity

SUBMITTER: Cox PB 

PROVIDER: S-EPMC12323367 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature