Association of Placental Pathology and Antibiotic Exposure after Birth with the Severity of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study.

ABSTRACT: This study aimed to assess the relationship between placental lesions, antibiotic exposure duration, and necrotizing enterocolitis (NEC) severity in preterm infants.In this single-center, case-control study, 107 infants with NEC and 130 controls were grouped by antibiotic exposure after birth: ≤3 or >3 days.Of 212 infants, 103 (48.5%) received antibiotics for ≤3 days, while 109 (51.5%) received antibiotics for >3 days. Multivariate regression analysis demonstrated that prolonged antibiotic duration (>3 vs. ≤3 days) was significantly associated with increased severity of NEC, with adjusted odds ratios (aORs) of 2.65 (95% confidence interval [CI]: 1.36-5.16; p = 0.004) for medical NEC and 3.36 (95% CI: 1.56-7.23; p = 0.002) for surgical NEC. However, prolonged antibiotic durati

SUBMITTER: Garg PM 

PROVIDER: S-EPMC12323401 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature