Immunophenotype-guided interpretable radiomics model for predicting neoadjuvant anti-PD-1 response in stage III-IV d-MMR/MSI-H colorectal cancer.

ABSTRACT:

Background

Neoadjuvant immunotherapy significantly improves the pathological complete response (pCR) rate in colorectal cancer (CRC). However, the lack of reliable tools to accurately identify responders remains a key barrier to its widespread clinical adoption. This study aimed to develop an interpretable radiomics model guided by immunophenotypes to predict response to preoperative immunotherapy in CRC, with the goal of enabling more precise and personalized treatment strategies.

Methods

First, we retrospectively collected 108 patients with CRC from the center who underwent preoperative CT and RNA sequencing. Immunophenotypes were characterized through unsupervised clustering of tumor-infiltrating immune cells at RNA level, with subsequent validation by CD3 and CD8 spatial

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12323523 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature