Obstructive sleep apnoea and risk of dementia: a Danish population-based cohort study.

ABSTRACT:

Background

Obstructive sleep apnoea (OSA) is associated with adverse health outcomes. However, the association with dementia remains uncertain. Thus, we examined the association of OSA with all-cause dementia and Alzheimer's disease.

Methods

We conducted a Danish nationwide population-based cohort study using health registries. Patients with OSA were identified from 1995 to 2017. Furthermore, a propensity score-matched comparison cohort was defined. Propensity scores were computed based on age, sex, comorbidities and education. With follow-up until 2018, we computed incidence rates (IRs) and HRs for all-cause dementia and Alzheimer's disease. Subgroup analyses were conducted by sex, age, overweight/obesity, hypertension and continuous positive airway pressure (CPAP) treatmen

SUBMITTER: Gribsholt SB 

PROVIDER: S-EPMC12323540 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature