A General Platform for Copper-Catalyzed Atom Transfer Radical Addition with Electron-Deficient Olefins.

ABSTRACT: We disclose a broad platform for copper-catalyzed atom transfer radical addition (ATRA) of electron-deficient olefins. Catalytic Cu(dtbbpy)₂(OTf)₂ enables radical addition of electron-deficient alkyl halides to acrylates, acrylamides, and vinyl sulfones in fair to excellent yields. The resultant ATRA products can be used in a variety of telescoped reactions, including substitution with basic amine nucleophiles to afford α-amino esters. The synthetic utility of the products is further demonstrated through derivatization to give substituted cyclopropanes and a γ,δ-unsaturated ester.

SUBMITTER: Wendlandt HC 

PROVIDER: S-EPMC12323560 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature