African swine fever virus MGF505-3R facilitates ferroptosis to restrict TBK1-IRF3 pathway.

ABSTRACT: African swine fever virus (ASFV) causes hemorrhagic, severe infectious diseases and serious economic losses to the pig industry. ASFV multigene family 505 can antagonize the host's innate immunity through multiple signaling pathways and is considered an important target for vaccine development. However, the mechanism by which it induces host cell damage remains unclear. In this study, we observed that ASFV infection, similar to RSL3, can induce ferroptosis with the accumulation of reactive oxygen species (ROS) and iron, decrease glutathione peroxidase 4 (GPX4) expression, and restrain the Kelch-like ECH-associated protein 1-nuclear factor E2-related factor (Keap1-Nrf2) pathway. Moreover, the expression of ferroptosis biomarkers (LOX and PTGS2) has been moderately upregulated. Some proteins

SUBMITTER: Niu S 

PROVIDER: S-EPMC12323604 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature