Pentamidine inhibition of streptopain attenuates <i>Streptococcus pyogenes</i> virulence.

ABSTRACT: The obligate human pathogen Streptococcus pyogenes (also known as GAS; Group A Streptococcus) carries high morbidity and mortality, primarily in impoverished or resource-poor regions. The failure rate of monotherapy with conventional antibiotics is high, and invasive infections by this bacterium frequently require extensive supportive care and surgical intervention. Thus, it is important to find new compounds with adjunctive therapeutic benefits. The conserved secreted protease streptopain (Streptococcal pyogenic exotoxin B; SpeB) directly contributes to disease pathogenesis by inducing pathological inflammation, degrading tissue, and promoting the evasion of antimicrobial host defense proteins. This study screened 400 diverse off-patent drugs and drug-like compounds for inhi

SUBMITTER: Trivedi K 

PROVIDER: S-EPMC12323618 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature