Genomic variability of lipooligosaccharide biosynthesis locus and sequence type among <i>Campylobacter jejuni</i> isolated from patients with Guillain-Barre syndrome.

ABSTRACT: Lipooligosaccharide (LOS) is a crucial component of the Campylobacter jejuni (C. jejuni) cell membrane that mimics human gangliosides and can induce autoimmune neuropathies like Guillain-Barré syndrome (GBS). Approximately one in 1,000 C. jejuni infections leads to GBS, with LOS variations influencing immune response and disease induction. We aimed to investigate the sequence type and genomic variation of the LOS region of C. jejuni strains isolated from patients with GBS and enteritis. We isolated 38 GBS- and 24 enteritis-associated C. jejuni strains from Bangladesh, sequenced them on the Illumina platform, and compared their LOS regions using various bioinformatic approaches. Comparative genomic analysis between GBS-associated and enteritis-associated s

SUBMITTER: Nayeem MAJ 

PROVIDER: S-EPMC12323628 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature