Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure.

ABSTRACT:

Objectives

Intercellular adhesion molecule-1 (ICAM-1) is a glycoprotein expressed on immune, endothelial, and epithelial cells. In the setting of inflammation, it becomes upregulated and spliced into a soluble form (soluble ICAM-1 [sICAM-1]). This study examined the association of sICAM-1 with clinical outcomes in two large pediatric cohorts with acute respiratory distress syndrome (ARDS) and acute respiratory failure (ARF) and examined the relationships between sICAM-1 and other protein biomarkers utilizing network analysis to contextualize its role in ARDS pathophysiology.

Design

Secondary analysis of prospective cohort studies.

Setting

Multicenter PICUs.

Patients or subjects

Critically ill children with ARDS (Pediatric Acute Lung Injury [PALI], 2008-2014) an

SUBMITTER: Lim MJ 

PROVIDER: S-EPMC12323721 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature