IBzH (IBenzhydryl): Sterically-Flexible <i>N</i>-Aliphatic <i>N</i>-Heterocyclic Carbenes (NHCs) for Iron-Catalyzed C(sp³)-C(sp²) Cross-Coupling of Unactivated Haloalkanes.

ABSTRACT: Iron-catalyzed cross-coupling has emerged as a pivotal concept for the synthesis of valuable products across various facets of chemical research, including pharmaceuticals, organic materials and biological probes. In this respect, the use of N-heterocyclic carbenes (NHCs) as ancillary ligands to iron has been particularly powerful. However, the major limitation is that the successful iron-catalytic systems have been almost exclusively limited to N-aryl-N-heterocyclic carbenes, which significantly restricts future developments of this commanding catalysis platform. Herein, we report IBzH (IBenzhydryl), a class of N-heterocyclic carbenes that are based on benzhydryl substitution of the imidazole ring. We demonstrate that this N-alkyl yet sterically-flexible

SUBMITTER: Kardela M 

PROVIDER: S-EPMC12323741 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature