Pharmacotherapy for children with central precocious puberty or early puberty: A systematic review and meta-analysis.

ABSTRACT:

Background

The intervention of gonadotropin-releasing hormone agonist or in combination with recombinant human growth hormone (rhGH) is still controversial for children with central precocious puberty (CPP) or early puberty (EP). This study aimed to systematically review and compare the efficacy and safety of current therapeutic regimens for CPP or EP based on different timings of intervention.

Methods

We searched 7 databases and 2 registers for available studies from inception until December 2023. Two independent reviewers screened literature, extracted data, and assessed the risk of bias. Eligible data from randomized controlled trials and non-randomized studies of interventions were synthesized with meta-analysis and further performed subgroup analysis.

Results

A t

SUBMITTER: Yang C 

PROVIDER: S-EPMC12323909 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature