Causal association between inflammatory cytokines and osteonecrosis: A bidirectional 2-sample Mendelian randomization study.

ABSTRACT: Increasing evidence suggests that immune-inflammatory responses are closely associated with osteonecrosis (ON). However, the specific inflammatory regulators involved in this pathogenesis remain unclear. Using a bidirectional Mendelian randomization (MR) investigation, we methodically investigated circulating inflammatory proteins that are causally linked to osteonecrosis. The genetic tools for 91 inflammatory circulating proteins were from a genome-wide association study with 14,824 participants, most of whom were from Europe. The ON summary statistics were acquired from the FinnGen database. The main strategy for drawing conclusions about causality was the inverse-variance weighted (IVW) method. The final results were supported by a number of sensitivity studies, including MR-Egger, weig

SUBMITTER: You W 

PROVIDER: S-EPMC12323912 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature