Safety of esaxerenone (CS-3150) and its impacts on blood pressure and renal function: A systematic review and meta-analysis.

ABSTRACT:

Background

The safety and efficacy of esaxerenone (ESAX), a novel nonsteroidal mineralocorticoid receptor antagonist, remain insufficiently explored in systematic reviews and meta-analyses (SR/MA). This SR/MA aimed to investigate the safety and effects of ESAX on blood pressure (BP) and renal function.

Methods

Multiple databases and registers were systematically searched to identify randomized controlled trials and real-world studies evaluating the safety and efficacy of ESAX in various conditions. The primary outcome was the risk of adverse events (AEs); secondary outcomes included its effects on BP and renal parameters.

Results

This SR/MA included 22 studies (N = 4699); 6 studies (5 randomized controlled trials and one retrospective study; n = 3211) with comparator

SUBMITTER: Kamrul-Hasan ABM 

PROVIDER: S-EPMC12323939 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature