Reevaluating the standard: A bidirectional Mendelian randomization study of autoimmune thyroiditis and thyroid function.

ABSTRACT: Previous studies have yielded inconsistent results regarding the causal relationship between autoimmune thyroiditis (AIT) and thyroid function. This study employs the Mendelian randomization (MR) method to clarify the connection between AIT and thyroid function. We conducted a comprehensive statistical analysis using data from publicly available genome-wide association studies focusing on individuals of European ancestry. A 2-sample MR approach was used to explore the causal relationship between AIT and thyroid function. Single nucleotide polymorphisms served as instrumental variables, with the inverse-variance weighted (IVW) method as the primary analytical technique. Additional analyses included MR-Egger regression, the weighted median estimator, the simple-mode, and the weighted-mode. C

SUBMITTER: Sun X 

PROVIDER: S-EPMC12323941 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature