Exploring causal pathways between hypertension, lipid levels, and gout: Insights from Mendelian randomization and NHANES observations.

ABSTRACT: Gout, a common form of inflammatory arthritis, is caused by the deposition of monosodium urate crystals in joints and soft tissues. While associations between hypertension, lipid levels, and gout have been explored, their causal relationships remain unclear. This study aimed to examine the causal effects of hypertension and lipid levels on gout using multivariable Mendelian randomization (MR) and observational data from the National Health and Nutrition Examination Survey. We combined data from National Health and Nutrition Examination Survey (2006-2016) and genetic information from genome-wide association studies to investigate the associations between hypertension, lipid levels (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides (TG), and total chole

SUBMITTER: Li M 

PROVIDER: S-EPMC12323965 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature