Psychosocial Impact of Postmastectomy Lymphedema Syndrome: Insights From a National Claims Database Analysis of Antidepressant Prescription Fills.

ABSTRACT:

Background

Postmastectomy lymphedema syndrome (PMLS) has been associated with lower quality of life due to symptoms and financial consequences. This study assessed the impact of PMLS on psychosocial well-being using antidepressant fill patterns. We hypothesized that PMLS increased the odds and duration of antidepressant fills.

Methods

Mastectomy encounters in the Merative MarketScan Research Databases, 2007-2022, were extracted using Current Procedural Terminology codes. Among these, patients who developed PMLS and filled antidepressant prescriptions were identified using the International Classification of Diseases, Ninth and Tenth Revision, codes and generic drug names. Univariate and multivariate logistic regression tests were performed for statistical analyses.

SUBMITTER: Najafali D 

PROVIDER: S-EPMC12324019 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature