The association between serum leptin levels, body mass index, and disease activity in women with systemic lupus erythematosus.

ABSTRACT: Obesity is related to a dysregulation in circulating adipokines and might have a potential role in the pathogenesis of systemic lupus erythematosus (SLE). This study aimed to determine the association between serum leptin levels, body mass index (BMI), and disease activity in women with SLE. Female SLE patients were included in the study. Demographic data, clinical manifestations, comorbidities, and serum leptin levels were collected at baseline. The weight statuses were defined as; normal: BMI 18.5 to 24.9 kg/m2; overweight: BMI 25 to 29.9 kg/m2; and obese: BMI ≥ 30 kg/m2. The SLE Disease Activity Index 2000 (cSLEDAI-2K) in clinical domains, Systemic Lupus International Collaborating Clinic/American College of Rheumatology Damage Index and BMI were reviewed over the 1-year prior to enroll

SUBMITTER: Aeamsaard N 

PROVIDER: S-EPMC12324021 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature