Breast Cancer Hormone Therapy Modulates Breast Implant Capsular Contracture.

ABSTRACT:

Background

Capsular contracture results in significant morbidity for patients with implant-based breast reconstruction, often requiring revisional operations. Preclinical studies have shown that hormone therapy, such as tamoxifen, may mitigate capsule formation. We analyzed capsular contracture rates in breast cancer patients already on hormone therapy who underwent implant-based reconstruction to determine if hormone therapy reduced these rates.

Methods

A retrospective case-control analysis reviewed breast implant surgery patients who underwent capsulectomy/capsulotomy between February 2013 and December 2021. Demographics, cancer treatment, and surgical details were collected. Univariate and multivariable logistic regression analyses were done to compare capsular contractur

SUBMITTER: Chawla M 

PROVIDER: S-EPMC12324050 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature