Concurrent use of low complexity automated NAATs for TB diagnosis and detection of resistance: A cost-effectiveness analysis.

ABSTRACT: Current TB diagnostics relying on respiratory samples are less effective in children (under 10 years), children living with HIV (CLHIV) and adult people living with HIV (PLHIV). Concurrent testing using low-complexity automated nucleic acid amplification tests (LC-aNAATs) on multiple sample types and Lateral Flow Lipoarabinomannan (LF-LAM) improves diagnostic performance, but concerns about cost-effectiveness remain. To inform WHO guideline development group (GDG) recommendation we developed stochastic decision analysis model to evaluate the cost-effectiveness of concurrent LC-aNAAT testing in these populations in Malawi and the Philippines. The analysis, conducted from a healthcare system perspective estimated incremental cost per disability-adjusted life year (DALY) averted using country

SUBMITTER: Shrestha SK 

PROVIDER: S-EPMC12324103 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature