Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization.

ABSTRACT:

Background

Subarachnoid haemorrhage (SAH) poses a life-threatening risk, contributing to half of all haemorrhagic strokes, with aneurysmal SAH (aSAH) affecting approximately 6 individuals per 100,000 annually. Following aSAH, the influx of plasma haptoglobin into the cerebrospinal fluid (CSF) is insufficient to sequester the released free haemoglobin in the subarachnoid space and avoid its neurotoxic effects. Exogenous administration of haptoglobin could be a therapeutic strategy for improving outcomes after aSAH.

Methods

Using individual level data in the UK Biobank and genetic summary statistics from the largest relevant cohorts, Mendelian randomization analysis was conducted to explore the associations of genetically predicted CSF haptoglobin with the risk of catastrophic

SUBMITTER: Kayode GA 

PROVIDER: S-EPMC12324130 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature