Genetic structure of different ethnic populations at the frontotemporal dementia risk loci.

ABSTRACT:

Background and purpose

Frontotemporal dementia (FTD) is a devastating neurodegenerative disorder affecting behavior, language, and cognition. It has a complex and still poorly understood genetic basis. The prevalence of FTD and other neurodegenerative disorders varies in populations of different ethnicities. This study aimed to analyze the genetic structure of different ethnic populations at FTD risk loci and provide insights into possible genetic factors underlying the above variation.

Methods

The data of single-nucleotide polymorphisms (in total 32) with genome-wide significance were extracted from the GWAS Database. The individual genotype data were retrieved from the 1000 Genomes Phase 3 Project. We analyzed several standard parameters of population genetic structure and

SUBMITTER: Mavrych V 

PROVIDER: S-EPMC12324132 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature